Fungi detected in 35 cancer types, often intracellular Cancer Fungi Intracellular CellCellPress WeizmannScience UCSanDiego UCSDMedSchool TelAvivUni ASU BarIlanU
Study: Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Image Credit: Kateryna Kon / Shutterstock
About the study In the present study, researchers profiled fungal DNA in two large cohorts of cancer samples, the Weizmann and Cancer Genome Atlas cohorts. They screened patients with 35 different cancers, obtained 17,401 patient tissue, blood, and plasma samples, and proceeded to characterize their cancer mycobiome.
Studies have shown that bacteriomes, immunomes, and mycobiomes demonstrate cancer-type specificity. It is, thus, likely that multi-domain fungal clusters vary across cancer types. The team compared WIS-overlapping fungal and bacterial genera in TCGA using a neural network method previously developed to estimate microbiome-metabolite co-occurrences.
Related StoriesCompared to matched bacteriomes, tumor-specific fungi had lower diversities and abundances. Interestingly, although fungi were present in all examined cancer types, not all tumors showed a positive fungal signal. However, imaging revealed that most fungi were intracellular, like intratumoral bacteria. In addition, Mycobiome richness was lower for WIS cohort than the TCGA cohort.
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