Frozen embryo transfers linked with highbloodpressure risks in pregnancy HeartNews
In vitro fertilization using frozen embryos may be associated with a 74% higher risk of hypertensive disorders in pregnancy, according to new research published today in. In comparison, the study found that pregnancies from fresh embryo transfers—transferring the fertilized egg immediately after in vitro fertilization instead of a frozen, fertilized egg—and pregnancy from natural conception shared a similar risk of developing a hypertensive disorder.
Researchers examined national data from medical birth registries from Denmark, Norway and Sweden of nearly 2.4 million women who were ages 20 to 44 years old who had single deliveries and gave birth during the study period—from 1988 through 2015. These data were the basis of a population-based study that also included a comparison of women who had both an IVF pregnancy and a naturally conceived pregnancy, called sibling comparison.
in pregnancy was substantially higher after frozen embryo transfer compared to pregnancies from fresh embryo transfer or natural conception."In the population analysis, women whose pregnancy was the result of a frozen embryo transfer were 74% more likely to develop hypertensive disorders in pregnancy compared to those who conceived naturally.
"Our sibling comparisons indicate that the higher risk is not caused by factors related to the parents, rather, however, that some IVF treatment factors may be involved," Petersen said."Future research should investigate which parts of the frozen embryo transfer process may impact risk of hypertension during pregnancy."
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