French hospitals revive discontinued transplant drug that has already saved 28 lives.
patients like Raphaël. The only possible treatment to cure it is fumagillin, an antiparasitic that has been used since the 1950s.The problem was that production of this medicine had stopped in 2019, and HCL's last stocks of fumagillin had been used up in March 2020. So, a support network consisting of multiple HCL departments, the French National Reference Center for Microsporidiosis at Clermont-Ferrand University Hospital, and the Fripharm pharmacists was set up.
"We contacted suppliers in India, China, and Europe," Camille Merienne, PharmD, PhD, pharmacist in charge of the Fripharm control laboratory, told Medscape."We searched the entire world to try to find a stock of active material!" In the end, the team learned that a stock of 300 g of raw material slated for destruction was available in Hungary."We were able to identify a production site that had this last remaining quantity. They agreed to deliver the raw material to us.
The news subsequently spread, and other patients in Lyon, Grenoble, Clermont-Ferrand, Paris, Bordeaux, Rennes, and Nantes were able to receive treatment, thanks to the fumagillin produced by Fripharm."Over the course of 18 months, we were able to treat 28 patients," said Pirot.But the 300 g of active ingredient recovered in Hungary will not last forever, and the platform's pharmacists are concerned about ensuring that this production continues.
"The fumagillin that we have succeeded in recreating at HCL is critically important. Without this remedy, immunocompromised patients, including all transplant patients infected with microsporidia, have almost no chance of surviving. We have to find solutions by any means, whether with the public authorities or in the private sector. It is inconceivable not to save patients when we know how to," said Rabodonirina in a press release.
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