Fly Fitness: How the Iditarod Protein Connects Exercise, Cold Resistance & Cell Repair

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Fly Fitness: How the Iditarod Protein Connects Exercise, Cold Resistance & Cell Repair
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The gene, dubbed Iditarod, seems responsible for exercise’s ability to clean up damaged cells. As the days get shorter and chillier in the northern hemisphere, those who choose to work out in the mornings might find it harder to get up and running. A new study in PNAS identifies a protein that, w

Researchers identified a protein in fruit flies that impacts exercise in cold conditions. This protein is related to human irisin, which plays a role in exercise benefits and cold adaptation. The study emphasizes the evolutionary significance of this gene family in both invertebrates and mammals, suggesting its crucial role in muscle damage repair during intense exercise.

“When we queried this gene in the human genome, a gene called FNDC5, which is a precursor to the protein irisin, was the top hit,” said Jun Hee Lee, Ph.D, of the U-M Department of Molecular and Integrative Physiology.

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