British fertility regulator reveals that at least one child has been born using mitochondrial replacement therapy, but details are scant
fertilization technique that involves the DNA of three people.Eight years after the United Kingdom became the first country to regulate the reproductive technique known as mitochondrial replacement, news has emerged that children have been born using the procedure.
Mitochondrial replacement therapy , which was legalized in the United Kingdom in 2015, is intended to prevent the inheritance of serious health conditions caused by mutations to mitochondria, cells’ energy-producing organelles; such mutations often affect the heart, brain and muscles.fertilization — involves moving nuclear genetic material from an egg or single-cell embryo with disease-causing mitochondria to a donor egg or embryo that has had its nuclear genetic material removed.
Knowing how well the procedures worked and whether the babies are free of mitochondrial disease is crucial, says Robin Lovell-Badge, a developmental biologist at the Francis Crick Institute in London, who gave a statement to the UK Science Media Centre. Lovell-Badge also wants to know “whether there is any risk of them developing problems later in life or, if female, if their offspring are at risk of having the disease.
It’s not clear why the proportion of potentially disease-causing mitochondria can increase so dramatically after mitochondrial transfer and during development. One possibility is that genetic factors enable the maternal mitochondrial lineage to replicate more efficiently than mitochondria in the donor egg or embryo, says Wells.
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