FDA briefing discusses different COVID-19 vaccination regimens US_FDA VaccineRegimen SARSCoV2 COVID19
By Neha MathurJan 25 2023Reviewed by Aimee Molineux Additionally, they proposed a system for updating these vaccines, similar to how influenza shots are updated.
In 2022, the Vaccines and Related Biological Products Advisory Committee held two meetings to discuss this framework for updated COVID-19 vaccine and SARS-CoV-2 strain composition for vaccines to be administered in the fall of 2022. Following these meetings, FDA authorized four monovalent COVID-19 vaccines in the United States of America.
This simplification of vaccine composition should reduce complexity, decrease vaccine administration errors due to the complexity of the number of different vial presentations, and potentially increase vaccine compliance by allowing clearer communication." Other meeting objectives are harmonizing the strain composition of all COVID-19 vaccines to most likely mRNA vaccines and transitioning to a single vaccine composition for primary series and booster vaccination. Shifting to one vaccine composition for primary and booster vaccination would further simplify current vaccine use. In all likelihood, it would be a bivalent vaccine using spike protein of ancestral SARS-CoV-2 strain and the Omicron BA.4/BA.5 subvariants.
There is growing evidence that hybrid immunity provides significant protection against COVID-19. Thus, a simplified immunization schedule, to be proposed by FDA on January 26, appears feasible. There is also adequate data on vaccine immunogenicity from multiple sources, including vaccine manufacturing firms, researchers, and observational studies.
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