Many patients with breastcancer who receive radiotherapy can still experience fatigue years after treatment; risk factors, including pain, insomnia, depression, baseline fatigue, and endocrine therapy were associated with long-term fatigue, new data show.
METHODOLOGYOverall, 1443 patients with breast cancer from the REQUITE study responded to the Multidimensional Fatigue Inventory 20 tool to assess five dimensions of fatigue: general, physical, and mental fatigue as well as reduced activity and motivation.
Investigators identified factors associated with fatigue at 2 years post-radiotherapy among a total of 664 patients without chemotherapy and 324 with chemotherapy.In general, levels of fatigue increased significantly from baseline to the end of radiotherapy for all fatigue dimensions and returned close to baseline levels after 1 to 2 years.
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