The article presents a thorough examination of Alzheimer's disease (AD), emphasizing early detection as critical due to the disease's progression through stages from normal cognition to mild cognitive impairment (MCI) and eventually dementia.
Frontiers JournalsAug 26 2024 The article presents a thorough examination of Alzheimer's disease , emphasizing early detection as critical due to the disease's progression through stages from normal cognition to mild cognitive impairment and eventually dementia.
Historical shifts in diagnostic approaches are detailed, showing a move from reliance on clinical evidence to the incorporation of biological indicators. The review outlines the evolution of diagnostic criteria, the introduction of biomarkers, and the potential impact of artificial intelligence in discovering new, minimally invasive biomarkers.
Advancements in biomarker research are highlighted, with a focus on neuroimaging, blood-based markers, metabolomics, exosomal microRNA, and the potential role of pathogens and endocrine dysregulation. The review suggests that these diverse biomarkers, when integrated, could significantly enhance early detection and disease management.
Related StoriesIn conclusion, the review stresses the necessity of early detection for effective intervention and the potential of non-cognitive symptoms and biomarkers in identifying AD before cognitive decline becomes apparent. It acknowledges the challenges of integrating these indicators into clinical practice and calls for further research to confirm their reliability and applicability in early diagnosis.
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