Our immune system is made up of multiple smart defenses built into our bodies – but if those defenses go haywire, it can lead to diseases such as multiple sclerosis (MS).
When the probiotics were placed into the guts of mice with induced conditions similar to MS,was suppressed in key regions in the brain. If the treatment works in humans, it could help with some of the most damaging diseases that currently exist.
As well as its long-lasting, self-sustaining application, what's also particularly promising about the treatment is that it's more precise than"Engineered probiotics could revolutionize the way we treat chronic diseases,""If we can use living microbes to produce medicine from within the body, they can keep producing the active compound as needed, which is essential when we consider lifelong diseases that require constant treatment.
To get the probiotic working, the team had to delve deeper into the function of dendritic cells in autoimmunity, which isn't yet fully understood. They found a newThese brakes don't function properly in people with autoimmune diseases, which leaves the body vulnerable.
Although the study involved mouse models with a similar condition to MS, other immune mediated diseases could be targeted in the same way. Autoimmune diseases affect some 5-8 percent of the population in the US, but limited treatment options are available – not least because drugs can struggle to
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