Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity PNASNews HopkinsMedicine harvardmed DanaFarber hormone hormones Parkinsons ParkinsonsDisease toxicity
By Dr. Liji Thomas, MDSep 15 2022Reviewed by Danielle Ellis, B.Sc. Parkinson’s disease is among the most common neurodegenerative disorders. It has no definitive treatment despite herculean efforts encompassing multiple types of drug targets and candidates.
Despite the best treatment, the progressive nature of the disorder remains unchanged, and its progression rate and underlying pathophysiology remain intact. Eventually, therefore, most patients reach a state of functional decline. In another experiment, FNDC5 expression using a viral vector restored memory in an AD mouse model. Irisin was demonstrated to be the key element in cognitive function regulation in four different experiments on mice.
What did the study show? The findings of this study indicate that the presence of irisin prevents α-syn formation within neurons following their exposure to α-syn PFF, which induces misfolding of this protein to a toxic compound. This protected the nerve cells against the toxic effects of α-syn PFF. Still more significantly, irisin blocked the accumulation of α-syn PFF and α-syn as well in the irisin-treated mice, though soluble α-syn monomers remained detectable at the same levels. It also prevented the emergence of the behavioral effects of α-syn PFF mediated by striatal damage.
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