More than 50% of COVID-19 deaths could have been prevented with better global vaccine distribution, says study northeastern NatureComms
). Hence, we assume a higher or an earlier availability of doses. For each counterfactual scenario, we estimate the impact of the changed vaccine rollout as the percent reduction in deaths during the simulation period compared to the actual vaccine rollout . We note how the scenario without vaccines could be used as an alternative baseline. The goal is to quantify the impact of vaccine inequities, hence we opted to select the factual rollout as the baseline.
The second counterfactual scenario investigates the impact of an earlier start of the vaccination campaigns without changes in allocation volume. In other words, this scenario considers a more equal timing in the allocation of vaccine doses. We take as a reference point the start of the vaccination campaign in the US which took place on December 14, 2020.
Fig. 3: Counterfactual scenarios - Deaths averted if countries had US-equivalent vaccination start date. Deaths averted expressed as a percentage with respect to the actual vaccination rollout , assuming United States start date of December 14, 2020. Averted deaths are computed over the simulation period . The median absolute number of deaths averted is reported above the inter-quartile range.In the counterfactual scenarios studied above, our modeling approach considers the same level of NPIs implemented in the factual scenario.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer - Nature CommunicationsThe molecular mechanisms underlying androgen production in prostate cancer remain to be explored. Here, the authors reveal an epigenetic mark, K130Ac on H2A, following dual-phosphorylation on SREBP1 promoting de novo androgen synthesis to overcome the pharmacological inhibition of androgen synthesis.
Read more »
Association of gout with brain reserve and vulnerability to neurodegenerative disease - Nature CommunicationsThe potential association between neurodegenerative disease risk and gout is not fully understood. Here the authors showed that gout is causally related to several measures of brain structure which may explain their higher vulnerability to dementia.
Read more »
Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity - Nature CommunicationsLooking at genes that are differentially responsive to pathogens depending on the genetic background may help in the identification of therapeutic targets in personalized medicine. Here, using challenge of monocytes with three pathogens the authors identified eQTL that are shared between pathogens and loci that are pathogen specific.
Read more »
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis - Nature CommunicationsOsteoarthritis is characterized by mechanically driven pain but lacks adequate treatments. Here, the authors show that inhibiting a mechanically-sensitive ion channel expressed by nociceptors reduces pain behaviors in mouse models of joint pain.
Read more »
Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes - Nature CommunicationsEnvironmental conditions during pregnancy contribute to offspring metabolic disease. Here, the authors show that immune cells reprogrammed in utero by maternal vitamin D deficiency increase lifetime diabetes risk in the offspring and are sufficient to transplant diabetes.
Read more »
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses - Nature Biomedical EngineeringDurable anti-tumour responses can be triggered by maximizing the cooperative phagocytic potency of macrophages through the disruption of the CD47–SIRPα macrophage checkpoint and by delivering a tumour-opsonizing monoclonal antibody.
Read more »