A Nature research paper identifies an immunosuppressive glycan-mediated mechanism that ensures feto-maternal tolerance during pregnancy
, Workflow. Plasma from non-pregnant or pregnant mice and humans was first run over species-specific Multiple Affinity Removal System columns to remove high abundance proteins, whose presence would obscure the detection of other glycopeptides. In one analysis , the MARS-depleted plasma was analyzed by mass spectrometry to identify endogenous proteins of potential placental origin bearing-linked glycans with terminal α-Sia.
identified 7 of the encoding genes to be likely expressed primarily if not exclusively by the conceptus. These genes and corresponding representative peptide species are shown in the table , and include
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
FSH blockade improves cognition in mice with Alzheimer’s disease - NatureA paper in Nature reports that FSH, a hormone that rises after menopause, acts on neurons to enhance neuropathology and cognitive decline in Alzheimer’s Disease model mice. These undesirable effects can be halted by blocking FSH’s actions
Read more »
Imaging of isotope diffusion using atomic-scale vibrational spectroscopy - NatureVibrational electron energy-loss spectroscopy is used to distinguish two stable isotopes of carbon and to monitor their diffusion with subnanometre spatial resolution.
Read more »
Knowledge about others reduces one’s own sense of anonymity - NatureWhen people learn more about a stranger, they feel like the stranger knows them better, a Nature paper reveals. Using this finding in the real world, the authors show that giving people information about their neighbourhood police officers may reduce crime
Read more »
Nature is trialling transparent peer review — the early results are encouragingLast year, nearly half of Nature authors agreed to publish anonymous referee reports. We hope that more will consider doing so this year.
Read more »
Molecular hallmarks of heterochronic parabiosis at single-cell resolution - NatureA transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked through enhanced mitochondrial function.
Read more »