Science, Space and Technology News 2023
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Historically, TRD has posed a significant challenge. A study from the National Institute of Mental Health revealed that while a third of patients with depression found remission with their initial treatment, subsequent treatments saw diminishing returns, with only 10-15% attaining remission by their third trial. This stark reality amplifies the need for more effective intervention strategies.
Study participants were split into two cohorts: one self-administered quetiapine XR at home, while the other received esketamine NS under hospital supervision. Concurrently, both groups continued their most recent antidepressant regimen with a conventional antidepressant, either a selective serotonin reuptake inhibitor or a serotonin and norepinephrine reuptake inhibitor . “The study spanned 32 weeks, which is longer than typical trials,” says Oliveira-Maia.
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