Dr Barney Graham, Time's 2021 Hero of the Year for his work on the COVID-19 vaccine, joins Dr Forest Arnold in this episode covering the groundbreaking work done to develop an RSV vaccine.
, and viruses like that, including coronaviruses. In RSV, the F protein is anchored in the membrane, and it starts out in one conformation, like a spring-loaded trap. As it approaches the cell, the top of it unfolds, and it inserts itself into the target cell membrane.
Once we had the protein in that form, it turned out to be a much better vaccine antigen. In animals, for instance, you could elicit 40-50, sometimes 80-fold higher neutralizing activity from the pre-fusion molecule than you could from a post-fusion molecule.We'll get back to those neutralizing antibodies, but first, we have to sidestep and talk about COVID-19 for a second.
Then, you move forward some more, and they're working on RSV vaccines, and here comes COVID-19. The technology gained from RSV gave us the ability to rapidly form a COVID-19 vaccine. Now, we're 3 years out from the COVID-19 vaccine, and we've got our first
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