Stress gene dysregulation found in kids after injury from abuse differs from that found after accidents luriechildrens
Survivors of child abuse experience high rates of adverse physical and mental health outcomes. Epigenetic alterations in the stress response system, thegene specifically, have been implicated as one mechanism that may link abuse to lifelong health issues.
promoter in buccal and blood cells, even after controlling for injury severity, socioeconomic status, and psychosocial risk factors.may occur at the earliest indication of abuse and may be associated with delayed resolution of the HPA axis stress response. Additional testing for epigenetic differences in larger sample sizes is needed to further verify these findings.FKBP5
promoter in buccal and blood cells at the time of initial diagnosis even after controlling for injury severity, socioeconomic status, and psychosocial risk factors. Early childhood physical abuse may impact the epigenetic regulation of the stress response system, including demethylation within promoters and enhancers of theThe findings are important because unmitigated stress is associated with adverse health outcomes throughout the life-course.
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