Adoptive T-cell therapy has revolutionized medicine. A patient's T-cells -; a type of white blood cell that is part of the body's immune system -; are extracted and modified in a lab and then infused back into the body, to seek and destroy infection, or cancer cells.
Georgia Institute of TechnologyJun 24 2024 Adoptive T-cell therapy has revolutionized medicine. A patient's T-cells -; a type of white blood cell that is part of the body's immune system -; are extracted and modified in a lab and then infused back into the body, to seek and destroy infection, or cancer cells.
By delivering miRNA in naïve T cells, we have basically prepared an infantry, ready to deploy. And when these naïve cells are stimulated and activated in the presence of disease, it's like they've been converted into samurais." Lean and mean Currently in adoptive T-cell therapy, the cells become stimulated and preactivated in the lab when they are modified, losing their naïve state. Singh's new technique overcomes this limitation.
"This process creates a well-programmed naïve T-cell ideal for enhancing immune responses against specific targets, such as tumors or pathogens," said Singh. Related StoriesAdoptive T-cell therapy is used against aggressive diseases that overwhelm the body's defense system. Scientists give the patient's T-cells a therapeutic boost in the lab, loading them up with additional medicine and chemically preactivating them.
Nanoprecision: The pointed solution Singh wanted to enhance naïve T-cells with a dose of miRNA, a molecule that, when used as a therapeutic, works as a kind of volume knob for genes, turning their activity up or down to keep infection and cancer in check. The miRNA for this study was developed in part by the study's co-author, Andrew Grimson of Cornell University.
The nanowires, silicon wafers made with specialized tools at Georgia Tech's Institute for Electronics and Nanotechnology, form a fine needle bed. Cells are placed on the nanowires, which easily penetrate the cells and deliver their miRNA over several hours. Then the cells with miRNA are flushed out from the tops of the nanowires, activated, eventually infused back into the patient. These programmed cells can kill enemies efficiently over an extended time period.
Blood Cancer Immune System Immunotherapy Medicine Nanotechnology Research T-Cell White Blood Cell
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