Increasing concerns regarding potentially harmful long-term effects of premenopausal bilateral oophorectomy (PBO) have caused a decline in the number of women choosing to proactively remove both ovaries as a precaution to protect against ovarian cancer.
to multiple tissues and organs, including the brain, muscles, bone, blood vessels, heart, and the gastrointestinal tract.
Some prior research also has suggested that there could be an association with cardiovascular disease,, or dementia. Most of these studies noted that risk was greatest for women who underwent PBO before the age of 46 years. However, these earlier studies were based on the passive collection of outcomes primarily through medical record abstraction. In this new study involving more than 500 women, of which slightly more than half had undergone PBO, in-person assessments were completed, on average, 22 years after the PBO.
Compared with the women who had not had PBO, those who underwent the procedure when they were aged younger than 46 years had increased risk of arthritis, asthma, obstructive sleep apnea, and bone fractures. They also walked a shorter distance during a 6-minute walk. Women with a history of PBO when aged 46 to 49 years had increased risk of arthritis andNo significant differences in cognitive status were identified between the two groups of women.
"These results highlight the potential negative long-term effects of premenopausal bilateral oophorectomy and are important for women at average risk for ovarian cancer to consider when weighing the risks and benefits of bilateral oophorectomy with or without hysterectomy before menopause," says Dr. Stephanie Faubion, medical director for The Menopause Society.Michelle M.
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