A study published in the European Heart Journal reveals that fat accumulation in early or mid-adulthood adversely impacts heart structure and function in individuals aged 60-64, highlighting the importance of managing adiposity throughout life.
By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Jul 21 2024 Obesity is an established risk factor for heart disease ; however, it remains unclear how fat deposition in obesity alters the structure and function of the heart in older adults. A new paper published in the European Heart Journal discusses cardiac outcomes in individuals between 60 and 64 years of age following fat accumulation in early or mid-adulthood.
All study participants were repeatedly measured for adiposity. Both body mass index and waist-to-hip ratio values were calculated throughout the study participants' adult lives from the age of 20. Between the ages of 60 and 64, an echocardiographic evaluation of heart structure and function was performed. These parameters included left ventricle structure/mass, relative wall thickness, internal LV diameter , and function during heart diastole.
Similar observations were made for MCF, which declined with increasing BMI from age 20. These effects were also explained by BMI between 60 and 64.After compensating for possible confounding factors, the heart's diastolic function decreased with increasing BMI from the age of 20 onwards. This was also attributed to the effect of adiposity or BMI at 60-64 years of age.
Conclusions The current study presents the results of the longest follow-up period in any birth cohort study in Britain. The study findings identified a link between increased fat deposition, as demonstrated by higher BMI/WHR, in early adult life, followed by deterioration of cardiac structure and impairment of cardiac function.
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