Two experimental drugs fail to prevent or slow mental decline in a study of people who are virtually destined to develop Alzheimer's disease at a relatively young age because they inherited rare gene flaws.
FILE - In this Aug. 14, 2018 file photo, a doctor looks at a PET brain scan at the Banner Alzheimers Institute in Phoenix. Two experimental drugs failed to prevent or slow mental decline in a study of people who are virtually destined to develop Alzheimer's disease at a relatively young age because of rare gene flaws. The results announced Monday, Feb.
“We actually don't even know yet what the drugs did” in term of removing that protein because those results are still being analyzed, said study leader Dr. Randall Bateman at Washington University in St. Louis, Missouri. The study tested solanezumab by Eli Lilly & Co., and gantenerumab by Swiss drugmaker Roche and its U.S. subsidiary, Genentech. Both drugs gave disappointing results in some earlier studies, but the doses in this one ranged up to four to five times higher and researchers had hoped that would prove more effective.
"If you get one of these genetic mutations you're almost guaranteed to get Alzheimer's," typically in your 30s, 40s or 50s, said Dr. Eric McDade, another study leader at Washington University.
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