Does CBD mitigate harms of cannabis? Cannabis Cannabidiol Pharmacology Psychosis Tetrahydrocannabinol THC CBD npp_journal Sydney_Uni unipv UniofBath
By Dr. Liji Thomas, MDNov 20 2022Reviewed by Benedette Cuffari, M.Sc. Cannabis is a psychedelic drug being increasingly legalized throughout the western world for medicinal and recreational purposes. Simultaneously, more potent drug preparations are being used in terms of their ∆9-tetrahydrocannabinol concentrations. THC is known to cause acute adverse effects and may result in long-term impairments when consistently used in high doses.
Introduction Cannabis users who have a low frequency of use have been reported to develop acute loss of memory and attention with high-THC cannabis preparations, along with psychotic symptoms. Over more extended periods of use, this could result in a greater likelihood of psychosis and developing cannabis use disorder.
The study participants first inhaled cannabis, following which they completed a set of cognitive tasks and were assessed for pleasurable effects based on their enjoyment of chocolate and music compared to baseline. The participants were then asked to purchase something from a hospital shop. Positive psychotic effects were significantly greater following inhalation, with half of the total participants showing an increase in their PANSS-P scores by three points compared to baseline at all ratios and without significant differences between ratios. Psychotic thoughts also increased across the cohort without any difference between different ratios.Other tests showed that pleasurable effects or euphoria were evenly distributed, irrespective of the CBD:THC ratio.
Furthermore, the presence of CBD at increasing ratios did not change the subjective feeling of being high or the pleasurable effects of THC. The primary observation that CBD does not modulate THC's psychotic or cognitive effects corroborates earlier studies; however, two previous studies reported a weakening of such effects with CBD. These used larger doses of CBD that are often greater than those usually present in medicinal or recreational cannabis. Such doses may require non-inhalation routes of administration.
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