Do SSRIs lower the risk of long COVID? medrxivpreprint NIH ncats_nih_gov SSRI seratonin longCOVID PASC SSRIs COVID19 coronavirus covid
By Dr. Chinta SidharthanNov 15 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers conducted a retrospective study to determine whether selective serotonin reuptake inhibitors with immunomodulatory and antiplatelet properties can decrease the risk of post-acute sequelae of coronavirus disease 2019 .
While the pathophysiology remains unclear, hypothesized mechanisms include immune dysfunction, viral reservoirs, hormone dysregulation, and the formation of microclots. About the study In the present study, the researchers used anonymized electronic health records from the National COVID Cohort Collaborative repository consisting of information on diagnoses, procedures, medications, lab tests, and demographic factors.
Statistical analyses compared patients receiving SSRI treatment with and without S1R agonism to patients without exposure to any SSRIs.
The study also indicated a reduced risk of severe clinical outcomes and hospitalization among patients who were administered fluvoxamine or other SSRIs in the early stages of COVID-19.
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