As a single organ, our skin is able to perform a broad repertoire of vital functions. Dermatology experts call for a reference guide to single-cell composition of normal human skin, which is still lacking. A grassroots movement to establish a 'Human Skin Cell Atlas' is taking shape, as reported in a review in the Journal of Investigative Dermatology.
The spatial scale represents how skin composition and characteristics vary across anatomical regions. The temporal scale represents changes to skin across the human lifespan. The gender scale represents gender-specific differences between skin sites and function. The ancestral origin scale, which affects skin characteristics and proclivity to disease. The wound response scale, where unwounded skin is distinct from the skin that is permanently altered after the innate, acute wound repair program.
Using single-cell RNA-sequencing technology, researchers can study gene expression signatures of many individual cells in tissues and then bioinformatically evaluate how they work together to perform tissue functions. Co-lead author Maria Kasper, Ph.D., from the Department of Cell and Molecular Biology at the Karolinska Institute, adds,"Because we are passionate about human skin biology and versed in single-cell methods, we put together this review as a guide for achieving the goal to generate the Human Skin Cell Atlas . This review, a roadmap of a kind, will be the first step, followed by a joint effort to generate the actual atlas.
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