Depression's heavy toll: Unraveling its impact on overall health in US adults

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Depression's heavy toll: Unraveling its impact on overall health in US adults
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Depression in US adults found to significantly raise risks of death, particularly from cardiovascular ailments. Increased awareness and treatment can mitigate impacts.

By Tarun Sai LomteOct 10 2023Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in JAMA Network Open, researchers assessed the associations between depression and mortality among adults in the United States .

Hazard ratios and 95% confidence intervals for CVD, IHD, and all-cause mortality were estimated using multivariable Cox proportional models. Mediation analysis examined whether alcohol use and the American Heart Association’s Life’s Essential -8 cardiovascular health metrics mediate associations. Related StoriesOverall, 1495, 497, and 209 all-cause, CVD, and IHD deaths occurred. All-cause mortality rates were 5.62, 7.79, and 9.48 per 1000 person-years for none/minimal, mild, and moderate-to-severe depression, respectively. Depression was significantly associated with an increased all-cause mortality risk.

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