Baseline mood and psychiatric symptoms may enhance beneficial responses to psychedelic therapies.
High doses of LSD have been tested on healthy subjects but failed to produce benefits.is a highly prevalent mental health condition. Because many patients fail to respond to standard therapies, there is a pressing need for alternative approaches. Recently, administration of single high doses of psychedelic compounds such as psilocybin and lysergic acid diethylamide , combined with supportive, have proven effective. Unfortunately, the high doses tested have several drawbacks.
The two groups of subjects, depressed and nondepressed, differed in several ways with their responses to low doses of LSD. The highly depressed patients were not more sensitive to LSD; however, they preferentially were more sensitive to certain aspects of the drug. The depressed patients reported a significantly greater improvement in mood, as measured by reports of vigor and elation.-like subjective effects from LSD.
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