Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in bipolar disorder - Molecular Psychiatry

Examining the patchwork of mutations contributing to bipolardisorder MolPsychiatry

We thank all the participants of this study. We thank Yuichiro Watanabe, Muneko Kataoka, and Nana Matoba for data collection; Keisuke Fukumoto, Sumie Goto, and Atsuko Komori for experimental assistance. We thank the Support Unit for Bio-Material Analysis at RIKEN CBS for experimental assistance, the Laboratory for Molecular Dynamics of Mental Disorders members at RIKEN for valuable discussion, and the RIKEN HOKUSAI team for managing the high-performance computing system.

The Bulgarian Trio Sequencing study is an accumulation of exome sequencing performed and/or funded by the Broad Institute, Cardiff University, Icahn School of Medicine at Mount Sinai, and the Wellcome Trust Sanger Institute. Work at the Broad Institute was funded by Fidelity Foundations, the Sylvan Herman Foundation and philanthropic gifts from Kent and Liz Dauten, Ted and Vada Stanley, and an anonymous donor to the Stanley Center for Psychiatric Research.

Masaki Nishioka, Naomi Sakai, An-a Kazuno, Mizuho Ishiwata, Junko Ueda, Atsushi Takata & Tadafumi Kato Laboratory for Molecular Pathology of Psychiatric Disorders, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, JapanDepartment of AI and Innovative Medicine, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8575, JapanDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8573, JapanStatistical Genetics Team, RIKEN Center for Advanced Intelligence...

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