Dedicated Molecular Nanocages for siRNA Delivery.
Apr 20 2023Reviewed by Bethan Davies Small interfering RNAs are new therapeutics that can be used to treat a variety of diseases. This has increased the need for safe, effective, and targeted methods of siRNA delivery in cells. Researchers from the University of Amsterdam and Leiden have now created customized molecular nanocages for siRNA delivery.
Related StoriesProf. Alexander Kros’ group at the Leiden Institute of Chemistry continued the studies. The researchers were motivated by the potential of siRNA in gene therapy, which requires effective delivery systems. A Range of Nanocages The nanocages are structures made of small molecular building blocks known as ditopic ligands that are joined together by metal atoms. The acronym M12L24 refers to a conventional cage, which has 12 metal atoms and 24 ligands. To create molecular cages with various siRNA binding affinities, the researchers developed and synthesized five distinct ligands.
Fluorescence measurements were taken after siRNA was successfully delivered to human GFP-expressing cells using the cages. HeLa and U2Os cell lines of the human species were both used. The M12L24 nanocages thus introduce the possibility of tuning siRNA delivery characteristics by tuning the nanocage composition.
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