Daily pill from Eli Lilly leads to 15% weight loss in mid-stage study, rivaling Wegovy results without the shot | CNN

Eli Lilly’s experimental pill for weight loss helped people lose an average of 15% of their body weight after 36 weeks on the highest dose in a midstage trial

The drug, orforglipron, had similar side effects as others in the class, known as GLP-1 receptor agonists: primarily gastrointestinal events like nausea, constipation and vomiting, researchers reported in a study published Friday in the New England Journal of Medicine. Results from the Lilly-funded trial were also presented at the American Diabetes Association conference in San Diego. Currently approved medicines for weight loss like Novo Nordisk’s Wegovy are given as once-weekly injections.

Participants on the medicine also had positive effects on levels of triglycerides and cholesterol, as well as systolic blood pressure, or the measure of pressure when the heart beats. There was no meaningful change in diastolic blood pressure, measuring pressure when the heart rests between beats. Side effects including nausea, constipation, vomiting and diarrhea were most common, the study showed.

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