Daily multivitamin improves cognitive function in seniors CognitiveFunction multivitamin Seniors Alzheimers Cancer ClinicalTrial Dementia BrighamWomens wakeforestmed harvardmed alzassociation
To date, no cognition-protective interventions for asymptomatic older adults have been authorized by the US FDA . Therefore, there is an urgent need to identify safe, affordable, accessible, and effective interventions to protect cognitive function among elders and reduce the societal burden associated with Alzheimer's disease and related dementia.
The COSMOS-Mind trial is ancillary to a pragmatic, placebo-controlled, large parent trial that used a two-by-two factorial design to assess the effectiveness of daily administration of CE and/or MVM supplementations in relation to cancer and cardiovascular disease outcomes. Related StoriesAmong the secondary outcomes were composite measures of episodic memory and executive function. Tertiary study outcomes were an abridged geriatric depression scale and cognitive change index . In addition, the COSMOS trial monitored adverse events , and those documented observed cognitive assessments were reported to the parent trial team.
In addition, COSMOS-Mind trial eligibility included patient age ≥65 years; no insulin use; and capability to finish the telephonic cognitive assessments. The COSMOS trial was randomized using computer-generated allocation listings. All participants, examiners, and investigators were masked concerning the interventions. Linear mixed-effect modeling was used for the analysis.
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