Researchers in a new Science study used electron cryo–electron microscopy to determine the structures of Aβ42 filaments from human brain. These structures aid in understanding the development of amyloid diseases. Learn more:
We thank the patients’ families for donating brain tissues; U. Kuederli, M. Jacobsen, F. Epperson, and R. M. Richardson for human brain collection and technical support; T. Saido for providingmice; T. Darling and J. Grimmett for help with high-performance computing; G. Singla Lezcano for help with Falcon 4i; and Y. Shi, J. Collinge, and C. Haass for helpful discussions. This study was supported by the Electron Microscopy Facility of the MRC Laboratory of Molecular Biology. M.G.
Maps have been deposited in the Electron Microscopy Data Bank with the accession codes EMDB 13800 and 13809. Atomic coordinates have been deposited in the Protein Data Bank under accession codes 7Q4B and 7Q4M. Please address requests for materials to the corresponding authors.
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