COVID-19's spike protein may contribute to blood vessels secreting fluids into a person's body, which can lead to severe health outcomes like respiratory failure, according to a study from researchers at the University of California, Berkeley.
The study, published Friday in the journal"Nature Communications," found that the spike protein on COVID virus particles can damage the walls of blood vessels throughout the body, causing a condition known as vascular leak.
Blocking the protein's damage to blood vessels could thus help prevent some of the virus' most serious symptoms and outcomes, according to the researchers. The spike protein can act similarly to the dengue virus protein NS1, according to the researchers. The dengue virus, spread by infected mosquitoes, can also cause vascular leak and lead to organ failure due to severe loss of blood or other fluids that make the heart pump.
"We had identified this protein secreted from dengue virus-infected cells that, even in the absence of the virus, is able to ... disrupt internal barriers," said Eva Harris, a senior author of the study and an infectious disease and vaccinology professor at UC Berkeley.
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