SuPAR Identifies Patients at High Risk of Blood Clot Formation A study from a COVID-19 cohort reveals an additional link between the immune system and blood clots, which could improve the treatment of critical illnesses. Blood clots are thought to occur in as many as a third of patients hospital
New research has revealed an additional link between the immune system and blood clots. This could result in improved treatment of critical illnesses.cohort reveals an additional link between the immune system and blood clots, which could improve the treatment of critical illnesses.
A team of researchers from around the world, including Salim Hayek, M.D., Medical Director of the University of Michigan Frankel Cardiovascular Center Clinics, and Shengyuan Luo, M.D., internal medicine resident physician at Rush University Medical Center, have been studying suPAR and its relationship to critical outcomes in COVID-19 cases.
The researchers, therefore, conceived that combining suPAR, a marker of the immune system, and D-dimer could improve the reliability of determining who is at high or low risk of blood clot formation among COVID hospitalized patients. “We had previously shown that patients with high suPAR levels are at much higher risk of death, kidney injury, respiratory failure needing mechanical ventilation and now venous thromboembolism,” said Hayek.In the study, scientists compiled data from 1,960 adults who were hospitalized for COVID-19 and who had their suPAR levels measured at the time of hospital admission. All patients were monitored until they were either discharged, or in some cases, until death.
Results showed that VTE occurred in 163 patients, and of those, 65 patients developed deep vein thrombosis, 88 patients developed a pulmonary embolus, and 10 patients developed both. Patients who developed blood clots had suPAR levels nearly 50% higher than those who did not develop clots. And, when suPAR levels were combined with D-dimer, researchers could classify 41% of study participants to have low-risk for occurrence of VTE.
Studying suPAR and its link to the immune system has positive implications for critical COVID-19 patients, and beyond.
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