COVID-19: Bacterial co-infection is a major risk factor for death, ICU admission and mechanicalventilation
Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 may be an important driver of mortality; however, these reports have not been validated with a multicenter, demographically diverse, cohort study with data spanning the pandemic.In this multicenter, retrospective cohort study, inpatient encounters were assessed for
bacterial co-infection risk factors and impact on primary outcomes were determined using multivariate logistic regressions and expressed as adjusted odds ratios with 95% confidence intervals .The studied cohorts included 13,781 bacterial co-infection was observed in patients with elevated ≥ 15 neutrophil-to-lymphocyte ratio within 48-h of hospital admission. Bacterial co-infection was found to confer the greatest increased risk for in-hospital mortality , ICU admission , and mechanical ventilation across both cohorts, as compared to other risk factors for severe disease. Observed mortality in
pandemic inpatients and was consistent across alpha, delta, and omicron SARS-CoV-2 variants.Elevated neutrophil-to-lymphocyte ratio is a prognostic indicator of
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Critical Supercars aero test kicks offSupercars has kicked off its last-ditch aero test as it looks to bring the parity saga to an end. RepcoSC
Read more »
Young man dead and girl 'critical' after horror three car crash in MilngavieThree people have been arrested over the crash
Read more »
Man dies and girl critical after Milngavie crashThe 21-year-old who died and a 16-year-old girl were both back seat passengers in the Milngavie crash.
Read more »
Man dies and girl critical after Milngavie crashThe 21-year-old who died and a 16-year-old girl were both back seat passengers in the Milngavie crash.
Read more »
Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome - Critical CareBackground Acute respiratory distress syndrome (ARDS) patients with different lung morphology have distinct pulmonary mechanical dysfunction and outcomes. Whether lung morphology impacts the association between ventilatory variables and mortality remains unclear. Moreover, the impact of a novel combined ventilator variable [(4×DP) + RR] on morality in ARDS patients needs external validation. Methods We obtained data from the Chinese Database in Intensive Care (CDIC), which included adult ARDS patients who received invasive mechanical ventilation for at least 24 h. Patients were further classified into two groups based on lung morphology (focal and non-focal). Ventilatory variables were collected longitudinally within the first four days of ventilation. The primary outcome was 28-day mortality. Extended Cox regression models were employed to explore the interaction between lung morphology and longitudinal ventilatory variables on mortality. Findings We included 396 ARDS patients with different lung morphology (64.1% non-focal). The overall 28-day mortality was 34.4%. Patients with non-focal lung morphology have more severe and persistent pulmonary mechanical dysfunction and higher mortality than those with focal lung morphology. Time-varying driving pressure (DP) was more significantly associated with 28-day mortality in patients with non-focal lung morphology compared to focal lung morphology patients (P for interaction = 0.0039). The impact of DP on mortality was more significant than that of respiratory rate (RR) only in patients with non-focal lung morphology. The hazard ratio (HR) of mortality for [(4×DP) + RR] was significant in patients with non-focal lung morphology (HR 1.036, 95% CI 1.027–1.045), not in patients with focal lung morphology (HR 1.019, 95% CI 0.999–1.039). Interpretation The association between ventilator variables and mortality varied among patients with different lung morphology. [(4×DP) + RR] was only associated with mortality in patients wi
Read more »
Plans to house asylum seekers in former village care home scrappedWestgate House in Gayton was earmarked as potential contingency accommodation for asylum seekers but the plan has since been abandoned
Read more »