Semaglutide and other drugs in its class are widely known for their role in managing type 2 diabetes and suppressing appetite.
, which could inform whether the effects of semaglutide in reducing alcohol drinking are related to the effects of semaglutide in the body.
Few of Dushay's patients smoke, she added, and she hadn't heard from patients about other behaviors like shopping or phone use. However, nausea is usually short-lived as patients develop a tolerance to semaglutide. It's also possible, Dushay and others said, that an overall blunting of pleasure responses could be behind the phenomenon.
"This is exactly why we have to do double-blind placebo-controlled studies, to look not only at the efficacy, as we hope, but also safety, in particular, because people with alcohol use disorder and addiction in general often have a comorbidity with other mental health problems, including depression," Leggio said, stressing the importance of monitoring closely for depressive symptoms.
"Are they identical? In which case, I don't really want to have everybody losing weight if they're trying to necessarily quit smoking or reduce their dependency, or can we get away with doses that are lower than those required to achieve weight loss?" Drucker said. "That's a really interesting question. And we just don't have good data to answer it."
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