Comprehensive new review of COVID-19vaccines shows they are effective WileyResearch
, or each other, and were published before 5 November 2021. Most trials were no longer than two months in length.
The following reduced or probably reduced the risk of severe or critical disease: Pfizer/BioNTech, Moderna, Janssen, Sputnik V, Bharat and Novavax. In addition, the Janssen and Soberana 2 vaccines probably decreased the risk of death from any cause. There were very few deaths recorded in all the trials and so evidence on mortality for the other vaccines is uncertain.
Given the evidence of efficacy of these vaccines, the researchers question whether further placebo-controlled trials are ethical. They suggest that further research should compare new vaccines with those already in use.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines - Genome MedicineBackground COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. However, little is known about the epigenetic alterations that occur in these cells during hyperinflammatory responses in severe COVID-19 patients. Methods In this study, we obtained the DNA methylome and transcriptome of peripheral blood monocytes from severe COVID-19 patients. DNA samples extracted from CD14 + CD15- monocytes of 48 severe COVID-19 patients and 11 healthy controls were hybridized on MethylationEPIC BeadChip arrays. In parallel, single-cell transcriptomics of 10 severe COVID-19 patients were generated. CellPhoneDB was used to infer changes in the crosstalk between monocytes and other immune cell types. Results We observed DNA methylation changes in CpG sites associated with interferon-related genes and genes associated with antigen presentation, concordant with gene expression changes. These changes significantly overlapped with those occurring in bacterial sepsis, although specific DNA methylation alterations in genes specific to viral infection were also identified. We also found these alterations to comprise some of the DNA methylation changes occurring during myeloid differentiation and under the influence of inflammatory cytokines. A progression of DNA methylation alterations in relation to the Sequential Organ Failure Assessment (SOFA) score was found to be related to interferon-related genes and T-helper 1 cell cytokine production. CellPhoneDB analysis of the single-cell transcriptomes of other immune cell types suggested the existence of altered crosstalk between monocytes and other cell types like NK cells and regulatory T cells. Conclusion Our findings show the occurrence of an epigenetic and transcriptional reprogramming of peripheral blood monocytes, which could be associated with the
Read more »
Bukayo Saka and Marcus Rashford bounce back as England eye World Cup glorySUMMER 2021, Bukayo Saka, 19, and Marcus Rashford, 23, both missed penalties in the final...
Read more »
China is dismantling its zero-covid machineIn recent days Beijing, Shanghai and many other cities announced that they would no longer require residents to show a recent negative test to enter shopping malls or to use public transport
Read more »
COVID-19 vaccination may cause temporary menstrual disturbances in adolescent girlsCOVID-19 vaccination may cause temporary menstrual disturbances in adolescent girls ChildHealth Coronavirus Disease COVID MenstrualPain Menstruation Folkehelseinst
Read more »
Wearing glasses does not reduce risk of COVID-19Wearing glasses does not reduce risk of COVID-19 Coronavirus Disease COVID Glasses EyeGlasses Ophthalmology JAMANetworkOpen Folkehelseinst OsloMet UniBasel Stanford berlinnovation
Read more »