Nature research paper: Common and rare variant associations with clonal haematopoiesis phenotypes
and/or VAF to test for potential differences between degree of clonal expansion and/or CHIP subtypes. Additional analyses were run restricting CHIP mutation calls to previously reported variants , as well as restricting to carriers ofmutations with at least one mutation in another CHIP gene. Controls were defined with two approaches: any individual without CHIP mutations and those without any genetic evidence of clonal haematopoiesis .
In UKB, cardiovascular disease was defined with the following ICD10 codes obtained from primary care, HES , or death registry data: I21, I22, I23, I252, I256, Z951, Z955, I248, I249, I241, I251, I255, I258, I259, I630, I631, I632, I633, I634, I635, I637, I638, I639, I651, ICD9 codes: 410, 412, and OPCS codes: K40, K41, K44, K45, K46, K49, K502, K75 and K471.
For the CVD models, we included sex, LDL, HDL, pack years, smoking status , BMI, essential primary hypertension, and type 2 diabetes mellitus as covariates. The results we reported used a composite of myocardial infarction , coronary artery bypass graft , percutaneous coronary intervention , and coronary artery disease , based on the coding described above, and also included death from any of these events.
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