Colchicine does not significantly reduce perioperative atrial fibrillation (AF) or myocardial injury after non-cardiac surgery (MINS) in patients undergoing major non-cardiac thoracic surgery, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.
Perioperative AF occurs in approximately 10% of patients after major thoracic surgery, while MINS has an incidence of about 20% in the same patient population. Patients with perioperative AF and MINS have a poor prognosis. High levels of inflammatory biomarkers have been associated with an increased risk of perioperative AF and MINS. Anti-inflammatory treatment therefore has the potential to reduce the incidence of these two prognostically important complications.
The study included 3,209 patients from 45 sites in 11 countries. The mean age was 68 years and 48.4% were women. Clinically important AF developed in 103 of 1,608 patients assigned to colchicine and 120 of 1,601 patients assigned to placebo, for a hazard ratio of 0.85 and absolute risk reduction of 1.1% . MINS occurred in 295 patients assigned to colchicine and 325 patients assigned to placebo, HR 0.89 and ARR 2.0% .
In post-hoc analyses, the composite outcome of clinically important perioperative AF or MINS occurred in 360 patients in the colchicine group and in 415 patients in the placebo group . The composite outcome of vascular mortality, nonfatal MINS, nonfatal stroke or clinically important perioperative AF occurred in 364 patients in the colchicine group versus 422 in the placebo group . Six patients had a stroke, 1 in the colchicine group and 5 in the placebo group .
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Resident fury after 'irresponsible' parking leaves parents on kerb for 30 minsA DISTRESSED Drumchapel woman revealed she was met with “smirking” and “rudeness” from carers who parked their car in front of a dropped…
Read more »
Man Utd receive huge boost with Rasmus Hojlund in line for debut vs ForestThe Danish striker is expected to be named on the bench on Saturday.
Read more »
Man Utd receive huge boost with Rasmus Hojlund in line for debut vs ForestThe Danish striker is expected to be named on the bench on Saturday.
Read more »
Leeds United's possible line-up after deadline day amid Piroe, Buonanotte linksLeeds United have until 11pm on September 1 to do business in the summer transfer window
Read more »
Notting Hill Carnival 2023: The line-up and what you need to knowEurope's biggest street party returns to west London for the 55th year.
Read more »
A4 Bath Road: Plans for relief road along old rail line criticisedA section of the A4 Bath Road in Bristol would only allow buses and bikes if plans go ahead.
Read more »