Science, Space and Technology News 2024
New research from Moffitt Cancer Center reveals that cells have a previously unknown information system based on ion gradients and the cytoskeleton, enabling rapid adaptation to environmental changes. This challenges traditional views of DNA as the only source of cellular information and could impact our understanding of cell function and cancer.Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges.
When information is received at some point on the cell membrane, it interacts with specialized gates in ion-specific channels, which then open, allowing those ions to flow along the pre-existing gradients to form a communication channel. The ion fluxes trigger a cascade of events adjacent to the membrane, allowing the cell to analyze and rapidly respond to the information.
This allows the cytoskeleton to act as a highly dynamic intracellular wiring network to transmit ion-based information from the membrane to the intracellular organelles, including mitochondria, endoplasmic reticulum, and the nucleus. The researchers suggested that this system, which allows for rapid and local responses to specific signals, can also generate coordinated regional or global responses to larger environmental changes.
They demonstrated their model was consistent with multiple experimental observations and highlighted several testable predictions arising from their model, hopefully paving the way for future experiments to validate their theory and shed light on the intricacies of cellular decision-making.
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