CDC recommendations and clinical considerations for the treatment of severe Mpox

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CDC recommendations and clinical considerations for the treatment of severe Mpox
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CDC recommendations and clinical considerations for the treatment of severe Mpox Mpox Treatment monkeypox rincidofovir cidofovir Tecovirimat CDCMMWR

​​​​​​​Report: Interim Clinical Treatment Considerations for Severe Manifestations of Mpox — United States, February 2023. ​​​​​​​Image Credit: CI Photos / Shutterstock

Medical countermeasures Current medical countermeasures for Orthopoxvirus infections include antivirals such as brincidofovir, tecovirimat, trifluridine ophthalmic solution, and cidofovir, and vaccinia immune globulin intravenous . Related StoriesPatients with severe Mpox could face complications such as hemorrhagic disease, necrotic lesions, obstructive lymphadenopathy and edema, sepsis, and extradermatologic manifestations of Mpox, such as encephalitis, ocular lesions, and pulmonary nodules.

Clinical considerations The report included comprehensive information on the manifestations of severe Mpox and the recommended treatments and management options. Ocular Mpox infections could manifest as redness, pain, drainage, lesions in and around the eye, periorbital swelling, and in severe cases, could lead to vision loss. Conjunctivitis, blepharitis, and keratitis are also associated with ocular manifestations of Mpox.

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