NFL predictions, picks, and odds for Arizona Cardinals vs San Francisco 49ers. NFL Week 4 betting best bet and game analysis.
The Cardinals were as low as +10.5 on the summer look-ahead but were 14-point dogs as of Sunday and reopened at a similar number despite knocking off the Cowboys straight up as a double-digit home dog last week.
The 49ers could be without their top wide receivers, as Deebo Samuel missed Wednesday’s practice likely due to the rib injury he picked up in Week 3 that was certainly scary at first glance. Brandon Aiyuk, who missed Week 3, was limited at practice on Wednesday as well. Linebacker Dre Greenlaw, who sits third on the team in tackles, was also DNP on Wednesday. The injuries are slightly more concerning, as the team has had extended rest after playing TNF in Week 3.
Weather-wise there is nothing standing out in this game that should warrant a move on the total. San Francisco continues to be one of the slowest-paced offenses in football with Arizona also ranking in the Bottom 10. If the San Francisco receivers can’t get healthy, I’d expect this total to fall closer to the opening 42.
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