Study sheds light on how breastcancer cells evade immune surveillance and survive in lymphnodes JExpMed
Disclosures: S. Chatterjee reported “other” from Takeda Pharmaceuticals, personal fees from FirstThought IO, Guidepoint, and Coleman Research, and non-financial support from PreScouter outside the submitted work; and is an employee of Takeda, consultant at FirstThought, Guidepoint, and Coleman Research, and a Medtech writer at PreScouter. S. Beyaz reported grants from Elstar Therapeutics, Revitope Oncology, and Atomic VC outside the submitted work. No other disclosures were reported.Z.
J.W. Van Wijnbergen’s current affiliation is University Medical Center Utrecht, Utrecht, Netherlands.W.W. Ho’s current affiliation is Singapore Immunology Network, Agency for Science, Technology and Research , Singapore, Singapore. J.M. Posada’s current affiliation is Warren Alpert Medical School of Brown University and Lifespan Academic Medical Center, Department of Pathology and Laboratory Medicine, Providence, RI, USA.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Associations between smoking and vaping prevalence, product use characteristics, and mental health diagnoses in Great Britain: a population survey - BMC MedicineBackground Rates of diseases and death from tobacco smoking are substantially higher among those with a mental health condition (MHC). Vaping can help some people quit smoking, but little is known about vaping among people with MHCs or psychological distress. We assessed the prevalence and characteristics (heaviness, product type) of smoking and/or vaping among those with and without a history of single or multiple MHC diagnoses and with no, moderate or serious psychological distress. Methods Data from 27,437 adults in Great Britain surveyed between 2020 and 2022. Multinomial regressions analysed associations between smoking, vaping and dual use prevalence, smoking/vaping characteristics and (a) history of a single or multiple MHC and (b) moderate or serious psychological distress, adjusted for age, gender, and socioeconomic status. Results Compared with people who had never smoked, those who currently smoked were more likely to report a history of a single (12.5% vs 15.0%, AOR=1.62, 95% CI=1.46–1.81, p|.001) or multiple MHCs (12.8% vs 29.3%, AOR=2.51, 95% CI=2.28–2.75, p|.001). Compared with non-vapers, current vapers were more likely to report a history of a single (13.5% vs 15.5%, AOR=1.28, 95% CI=1.11–1.48, p|.001) or multiple MHCs (15.5% vs 33.4%, AOR=1.66, 95% CI=1.47–1.87, p|.001). Dual users were more likely to report a history of multiple MHCs (36.8%), but not a single MHC than exclusive smokers (27.2%) and exclusive vapers (30.4%) (all p|.05). Similar associations were reported for those with moderate or serious psychological distress. Smoking roll-your-own cigarettes and smoking more heavily, were associated with a history of single or multiple MHCs. There were no associations between vaping characteristics and a history of MHCs. Frequency of vaping, device type and nicotine concentration differed by psychological distress. Conclusions Smoking, vaping and dual use were substantially higher among those with a history of MHC, especially multiple MHC, and ex
Read more »
β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancerAbstract. Intraepithelial lymphocytes (IELs) expressing γδ T-cell receptors (γδTCRs) play key roles in elimination of colon cancer. However, the precise mechanisms by which progressing cancer cells evade immunosurveillance by these innate T cells are unknown. Here, we investigated how loss of the Apc tumor suppressor in gut tissue could enable nascent cancer cells to escape immunosurveillance by cytotoxic γδIELs. In contrast with healthy intestinal or colonic tissue, we found that γδIELs were largely absent from the microenvironment of both mouse and human tumors, and that butyrophilin-like (BTNL) molecules, which can critically regulate γδIEL through direct γδTCR interactions, were also downregulated in tumors. We then demonstrated that β-catenin activation through loss of Apc rapidly suppressed expression of the mRNA encoding the HNF4A and HNF4G transcription factors, preventing their binding to promoter regions of Btnl genes. Re-expression of BTNL1 and BTNL6 in cancer cells increased γδIEL survival and activation in co-culture assays but failed to augment their cancer-killing ability in vitro or their recruitment to orthotopic tumors. However, inhibition of β-catenin signaling via genetic deletion of Bcl9/Bcl9l in either Apc-deficient or mutant β-catenin mouse models restored Hnf4a, Hnf4g, and Btnl gene expression and γδ T-cell infiltration into tumors. These observations highlight an immune-evasion mechanism specific to WNT-driven colon cancer cells that disrupts γδIEL immunosurveillance and furthers cancer progression.
Read more »
Life's new chapter for cancer survivor turned lottery winnerBreast cancer survivor Janice Gardner celebrates a £55,555 win from the People's Postcode Lottery 💸
Read more »
Jonnie Irwin wants people to learn from his mistake amid terminal cancer battleJonnie Irwin has spoken about his regret amid his terminal cancer battle and urges others not to make the same mistake.
Read more »
School inspired by headteacher raises £4,000 for cancer charityA team of teachers, staff, and current and former pupils at a Shrewsbury primary school have raised over £4,000 for Cancer Research in this year’s Race For Life.
Read more »
Jonnie Irwin shares one regret from cancer battleChannel 4 A Place In The Sun star has opened up as he continues to fight terminal lung cancer.
Read more »