MRI technology from Duke-led effort reveals the entire mouse brain in the highest resolution. Researchers from multiple universities have made a breakthrough in MRI technology, capturing the sharpest images ever of a mouse brain. This refined MRI, combined with light sheet microscopy, provides an
, the researchers generated scans of a mouse brain that are dramatically crisper than a typical clinical MRI for humans, the scientific equivalent of going from a pixelated 8-bit graphic to the hyper-realistic detail of a Chuck Close painting.
Although the researchers focused their magnets on mice instead of humans, the refined MRI provides an important new way to visualize the connectivity of the entire brain at record-breaking resolution. The researchers say new insights from mouse imaging will in turn lead to a better understanding of conditions in humans, such as how the brain changes with age, diet, or even with neurodegenerative diseases like“It is something that is truly enabling.
After Johnson and his team “scan the daylights out of it,” they send off the tissue to be imaged using a different technique called light sheet microscopy. This complementary technique gives them the ability to label specific groups of cells across the brain, such as dopamine-issuing cells to watch the progression of Parkinson’s disease.
One set of MRI images shows how brain-wide connectivity changes as mice age, as well as how specific regions, like the memory-involved subiculum, change more than the rest of the mouse’s brain.
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