Bivalent mRNA vaccines could enhance protective efficacy against COVID-19 CDCgov COVID19 SARSCoV2 Vaccine BivalentVaccine mRNA
By Dr. Liji Thomas, MDNov 23 2022Reviewed by Aimee Molineux The coronavirus disease 2019 pandemic led to intense activity among vaccine researchers to develop a safe and effective vaccine against the severe acute respiratory syndrome coronavirus 2 . The first to be developed, and so far the most effective, were the messenger ribonucleic acid vaccines from Pfizer/BioNTech and Moderna.
Introduction The first bivalent mRNA COVID-19 vaccine was recommended for use by the Advisory Committee on Immunization Practices at the beginning of September 2022. It contains elements of both the ancestral and the Omicron BA.4/BA.5 subvariants. In the current study, published in the Morbidity and Mortality Weekly Report released by the US Centers for Disease Control and Prevention , data on clinical effectiveness is drawn from the Increasing Community Access to Testing program, which aims to expand testing for the virus in socially backward communities. The formulation used here was the bivalent booster containing Omicron BA.4/BA.5 strains.
What did the study show? The testing results showed that about a third of the tests turned out positive, of which a quarter were unvaccinated. About 5% had received a bivalent booster, while the rest had obtained two to four monovalent vaccine doses. The relative vaccine effectiveness of the bivalent booster dose was calculated to be 30% and 56%, compared to that of two or more monovalent vaccine doses at 2-3, or eight months since the last dose, respectively, in the age group of 18-49 years.
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