Bats aren’t safe from new strains of COVID-19: study

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Bats aren’t safe from new strains of COVID-19: study
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Bats, the suspected species origin of COVID-19, are still capable of being infected by new strains of the virus, according to study of cross-species infectivity.

RIT scientists studied how the viral spike proteins in several SARS-CoV-2 variants interact with the host cell receptors known as ACE2 in both humans and various bats of genus Rhinolophus, pictured here. The study indicates COVID-19 is still highly transmissible between mammals.

“We were hoping to see really cool adaptive evolution happening as the virus got more used to humans and less used to bats, but we actually saw that there wasn’t a whole lot of change,” Gregory Babbitt, an associate professor with the Rochester Institute of Technology and one of the authors of the study,“Because this binding site has not evolved very much, there’s really not much stopping it from transmitting from humans to bats.

In order to see if any of these newer variants were no longer able to infect bats, researchers ran all current variants of concern against computer modelling of the binding receptors in these bats. These included the original strain of COVID-19, Alpha, Beta and Delta, as well as Omicron variants BA.1, BA.2 and BA.4/BA.5, among others.

Researchers found that all of the VOC were better at binding to a specific type of ACE2 receptor called hACE2, compared to bACE2, while the original strain of the virus saw no difference between which of these receptors it was capable of targeting. Although the vast majority of the transmission of COVID-19 has been human-to-human transmission, we’ve seen other animals catch the virus from humans as well during the course of the pandemic, including gorillas, tigers, minks and housecats.

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