A wave of baby deaths in the 1930s and 1940s was because of the vitamin D added to bread, milk and margarine. Most of those children would have had a gene mutation - but not all. Now scientists have discovered why some infants got sick even without the mutation.
Now, though, researchers at the University of East Anglia have discovered what is going on with these patients - and it's not due to a gene mutation, but their shape.
Where people don't have that mutation, but still struggle to process vitamin D, they can continue to have"lifelong problems without a proper diagnosis", he said.Shelley O'Connor, 34, from Norwich, was only diagnosed with HCINF1 11 years ago when she fell pregnant with her first child at the age of 23.
"It was very frightening," she said."I was really scared for the baby, but when I had an MRI, they found out that it was actually a kidney stone caused by taking vitamin D as a pregnancy supplement."The UEA team collaborated with colleagues at the Norfolk and Norwich University Hospital, where they worked with 47 patients like Shelley to find out how people could have the condition without the mutation.
Dr Green said:"A PhD student in my laboratory, Nicole Ball, carried out a more extensive genetic analysis of six patient blood samples and we found that the physical shape of the CYP24A1 gene in these apparent HCINF1 patients is abnormal.
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