axoCells™ sensory neurons are designed to enhance in vitro pain modeling, specifically tailored for advanced applications in neurological microfluidics systems, nociception modeling, and the assessment of analgesic drug targets.
Various environmental stimuli, such as touch, heat, and pain, trigger nerve cells known as sensory neurons . They are commonly used in microfluidic devices for cosmetic testing, pain models, and peripheral neurotoxicity models. Immunocytochemistry of axoCells Sensory Neurons show expression of the key marker TUJ-1, indicative of neuronal development, and the nociceptive ion channels TrpV1, Nav1.7, and Nav1.
Reduced neurite length results from treating axoCells Sensory Neurons with the chemotherapy drug paclitaxel, illustrating the functional significance of the sensory neurons. This offers a model for both chronic peripheral neurotoxicity and acute insult.Response of day 25 axoCells Sensory Neurons to paclitaxel, a chemotherapy reagent, applied at 2.6 days with wash-off at 4.6 days .
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