Auranofin inhibits SARS-CoV-2 replication Auranofin SARSCoV2 Coronavirus Disease COVID iScience_CP Sorbonne_Univ_ institutpasteur institut_curie
By Dr. Priyom Bose, Ph.D.Sep 6 2022Reviewed by Aimee Molineux The rapid outbreak of severe acute respiratory syndrome coronavirus-2 caused the ongoing coronavirus disease 2019 pandemic has claimed more than 6.5 million lives worldwide. Although the majority of the SARS-CoV-2 infected individuals experienced mild to moderate symptoms and did not require any special treatment, 20% of the infected population suffered from severe infection, and 5% required intensive care.
The entry of SARS-CoV-2 in human cells is facilitated by the interaction of the spike protein of the virus with heparan sulfate and the cleavage of S protein at the S1-S2 junction by Furin. Additionally, the cellular serine protease TMPRSS2 also plays an important role in the viral invasion of the host cell. These enzymes permit their binding to another host factor, namely, the membrane protein neuropilin-1 , and induce the merging of cell membranes.
Auranofin In this study, the FDA-approved drug library, Prestwick Chemical Library, was used for the high throughput screening based on the inhibition of cytokine-induced supramolecular complexes associated with NF-kB activation. However, Auranofin, a gold salt, exhibited strong anti-inflammatory properties with fewer side effects. In addition, this compound interfered with NF-kB activity by inhibiting IκB kinase .
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Antiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaquesAntiviral activity of favipiravir against Zika and SARS-CoV-2 in cynomolgus macaques Efficacy SARSCoV2 Coronavirus Disease COVID NatureComms
Read more »
Sensitivity of SARS-CoV-2 Omicron BA.2.75 to neutralization by monoclonal antibodies and seraSensitivity of SARS-CoV-2 Omicron BA.2.75 to neutralization by monoclonal antibodies and sera TheLancetInfDis ETH SARSCoV2 Omicron COVID19 coronavirus covid antibodies antibody
Read more »
Are current COVID-19 vaccines in England effective against severe BA.4 and BA.5 Omicron sub-lineage infections?Are current COVID-19 vaccines in England effective against severe BA.4 and BA.5 Omicron sub-lineage infections? medrxivpreprint LSHTM imperialcollege COVID19 coronavirus covid Omicron infection vaccine
Read more »
FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A - OncogeneOncogene - FOXA1 inhibits hypoxia programs through transcriptional repression of HIF1A
Read more »