Despite the risk posed by COVID-19, radiotherapy should be initiated without a delay of more than 6 days in patients with nonmetastatic nasopharyngeal carcinoma to ensure long-term survival – according to a study published in Cancer Cell International.
Since most of the EBV DNA load elevated between IC and CCRT, we used post-IC EBV DNA as a hierarchical factor and reanalyzed the association between treatment delay and changes in the EBV DNA load. We found that patients with an RT delay of6 days were at a higher risk of elevated EBV DNA load than those with an RT delay of < 6 days, regardless of whether EBV DNA after IC was detectable or not .The median follow-up time for DFS was 17.7 months .
Patients with EBV DNA elevation during treatment had a worse 1-year DFS , compared with those without EBV DNA elevation . In multivariable analysis, EBV DNA elevation during treatment remained an independent adverse factor for DFS .
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