Arthur D. Riggs 1939–2022 A world-renowned diabetes expert and molecular biologist, Art Riggs pioneered the lifesaving recombinant protein and antibody drugs on which the biotech industry was built
On 23 March, Arthur D. Riggs passed away at the age of 82 years. A pioneer in genetics and epigenetics, Riggs also made seminal contributions to biotechnology. The impact of his work shaped many areas of today’s molecular biology and biomedical sciences.Credit: City of Hope
Born in Modesto, California, a city with a name that mirrors his own character, Riggs spent his entire scientific career in Southern California. After earning his undergraduate degree from the University of California Riverside in chemistry, he received a PhD from Caltech, Pasadena, and continued with postdoctoral studies at the Salk Institute near San Diego.
Genetic engineering pioneers circa 1977. Keiichi Itakura and Arthur D. Riggs watch as data come in showing that they succeeded in producing an active human protein inRiggs is known for at least four far-reaching scientific discoveries and accomplishments: bidirectional DNA replication; developing a concept for the mechanism and function of mammalian DNA methylation; the first to clone and express recombinant human genes; and technology for generating recombinant antibodies.
In the late 1960s, along with fellow Caltech graduate student Joel Huberman, Riggs discovered that DNA in mammalian cells is replicated using multiple origins of replication in a bidirectional manner from a fork-like growing point
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