Shohei Ohtani struck out nine while pitching one-run ball into the fifth inning for the Angels, who lost their season opener for the eighth time in nine years.
The Los Angeles Dodgers will play the Angels in the first game at Dodger Stadium this year.
Ohtani didn't win, but he made more baseball history: He became the first player in baseball history to throw his team's first pitch of the season - a 99 mph fastball in the dirt to José Altuve - and to face his team's first pitch of the season at the plate. Mike Trout went 1 for 4 with a ninth-inning single in the three-time AL MVP's first game since missing the final 4 1/2 months of last season with an injured calf.
Ryan Pressly then got Tyler Wade to ground into a game-ending double play, earning the save several hours after the Houston closer agreed to a two-year, $30 million contract extension.
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