An oral and on-demand male contraceptive Contraceptive MaleContraceptive Efficacy Epididymis Sperm Testosterone Therapeutics Vasectomy NatureComms WeillCornell unibt
By Benedette Cuffari, M.Sc.Feb 16 2023Reviewed by Danielle Ellis, B.Sc. Current estimates indicate that about 50% of all pregnancies worldwide are unplanned. For men, the two available contraceptive options include a vasectomy or condoms, both of which are associated with certain limitations.
Recent advances in male contraceptives Several hormonal contraceptives have been investigated for their ability to interfere with spermatogenesis and ultimately limit the production of sperm. Despite success rates of up to 94% in clinical trials, most of these therapeutics were not pursued due to adverse side effects. Currently, a topical nestorone-testosterone gel is being investigated in many countries throughout the world.
What is sAC? Within the testes, specifically the cauda epididymis, mature sperm are stored in stable bicarbonate environment that is maintained at a concentration of about 5 millimolar . During ejaculation, the exposure of sperm to semen leads to a rapid exposure to much higher bicarbonate levels of about 25 mM and subsequent activation of sAC.
Oral sAC inhibitor is non-toxic and effective Drug Discovery eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Previously, the researchers of the current study identified several small molecule inhibitors that specifically target sAC in vitro to ultimately block several processes in both mouse and human sperm that are needed for fertilization.
The efficacy of a single oral dose of TDI-11861 in mice was confirmed by the lack of increased cAMP levels one and three hours after treatment.
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